Melatonin-induced increase in sensitivity of human hepatocellular carcinoma cells to sorafenib is associated with reactive oxygen species production and mitophagy

Effects of sorafenib in hepatocellular carcinoma (HCC) are frequently transient due to tumor-acquired resistance, a phenotype that could be targeted by other molecules to reduce this adaptive response. Because melatonin is known to exert antitumor effects in HCC cells, this study investigated whethe...

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Udgivet i:J Pineal Res
Main Authors: Prieto-Domínguez, Néstor, Ordóñez, Raquel, Fernández, Anna, Méndez-Blanco, Carolina, Baulies, Anna, Garcia-Ruiz, Carmen, Fernández-Checa, José C., Mauriz, José L., González-Gallego, Javier
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5018464/
https://ncbi.nlm.nih.gov/pubmed/27484637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jpi.12358
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