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Melatonin-induced increase in sensitivity of human hepatocellular carcinoma cells to sorafenib is associated with reactive oxygen species production and mitophagy

Effects of sorafenib in hepatocellular carcinoma (HCC) are frequently transient due to tumor-acquired resistance, a phenotype that could be targeted by other molecules to reduce this adaptive response. Because melatonin is known to exert antitumor effects in HCC cells, this study investigated whethe...

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Bibliografski detalji
Izdano u:J Pineal Res
Glavni autori: Prieto-Domínguez, Néstor, Ordóñez, Raquel, Fernández, Anna, Méndez-Blanco, Carolina, Baulies, Anna, Garcia-Ruiz, Carmen, Fernández-Checa, José C., Mauriz, José L., González-Gallego, Javier
Format: Artigo
Jezik:Inglês
Izdano: 2016
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5018464/
https://ncbi.nlm.nih.gov/pubmed/27484637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jpi.12358
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