Melatonin-induced increase in sensitivity of human hepatocellular carcinoma cells to sorafenib is associated with reactive oxygen species production and mitophagy

Effects of sorafenib in hepatocellular carcinoma (HCC) are frequently transient due to tumor-acquired resistance, a phenotype that could be targeted by other molecules to reduce this adaptive response. Because melatonin is known to exert antitumor effects in HCC cells, this study investigated whethe...

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Pubblicato in:J Pineal Res
Autori principali: Prieto-Domínguez, Néstor, Ordóñez, Raquel, Fernández, Anna, Méndez-Blanco, Carolina, Baulies, Anna, Garcia-Ruiz, Carmen, Fernández-Checa, José C., Mauriz, José L., González-Gallego, Javier
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5018464/
https://ncbi.nlm.nih.gov/pubmed/27484637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jpi.12358
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