Prediction of Human Pharmacokinetics of Antibody–Drug Conjugates From Nonclinical Data

Prediction of human pharmacokinetics (PK) based on preclinical information for antibody–drug conjugates (ADCs) provide important insight into first‐in‐human (FIH) study design. This retrospective analysis was conducted to identify an appropriate scaling method to predict human PK for ADCs from anima...

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Gepubliceerd in:Clin Transl Sci
Hoofdauteurs: Li, Chunze, Zhang, Cindy, Deng, Rong, Leipold, Douglas, Li, Dongwei, Latifi, Brandon, Gao, Yuying, Zhang, Crystal, Li, Zao, Miles, Dale, Chen, Shang‐Chiung, Samineni, Divya, Wang, Bei, Agarwal, Priya, Lu, Dan, Prabhu, Saileta, Girish, Sandhya, Kamath, Amrita V.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: John Wiley and Sons Inc. 2019
Onderwerpen:
Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6742937/
https://ncbi.nlm.nih.gov/pubmed/31115997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cts.12649
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