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Beyond the Ligand: Extracellular and Transcellular G Protein–Coupled Receptor Complexes in Physiology and Pharmacology

G protein–coupled receptors (GPCRs) remain one of the most successful targets of U.S. Food and Drug Administration–approved drugs. GPCR research has predominantly focused on the characterization of the intracellular interactome’s contribution to GPCR function and pharmacology. However, emerging evid...

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Pubblicato in:Pharmacol Rev
Autori principali: Dunn, Henry A., Orlandi, Cesare, Martemyanov, Kirill A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Pharmacology and Experimental Therapeutics 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6742926/
https://ncbi.nlm.nih.gov/pubmed/31515243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/pr.119.018044
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