Fine-Tuning of PGC1α Expression Regulates Cardiac Function and Longevity

RATIONALE: PGC1α represents an attractive target interfering bioenergetics and mitochondrial homeostasis, yet multiple attempts have failed to upregulate PGC1α expression as a therapy, for instance, causing cardiomyopathy. OBJECTIVE: To determine whether a fine-tuning of PGC1α expression is essentia...

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Veröffentlicht in:Circ Res
Hauptverfasser: Zhu, Xudong, Shen, Weiyan, Yao, Ke, Wang, Hu, Liu, Bo, Li, Tangliang, Song, Lijuan, Diao, Daojun, Mao, Genxiang, Huang, Ping, Li, Chengtao, Zhang, Hongbo, Zou, Yejun, Qiu, Yugang, Zhao, Yuzheng, Wang, Wengong, Yang, Yi, Hu, Zeping, Auwerx, Johan, Loscalzo, Joseph, Zhou, Yong, Ju, Zhenyu
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6742548/
https://ncbi.nlm.nih.gov/pubmed/31412728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.119.315529
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