Coupling to Gq Signaling Is Required for Cardioprotection by an Alpha-1A-Adrenergic Receptor Agonist

RATIONALE: Gq signaling in cardiac myocytes is classically considered toxic. Targeting Gq directly to test this is problematic, because cardiac myocytes have many Gq-coupled receptors. OBJECTIVE: Test whether Gq coupling is required for the cardioprotective effects of an alpha-1A-adrenergic receptor...

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Publicat a:Circ Res
Autors principals: Myagmar, Bat-Erdene, Ismaili, Taylor, Swigart, Philip M., Raghunathan, Anaha, Baker, Anthony J., Sahdeo, Sunil, Blevitt, Jonathan M, Milla, Marcos E., Simpson, Paul C.
Format: Artigo
Idioma:Inglês
Publicat: 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6742539/
https://ncbi.nlm.nih.gov/pubmed/31426700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.118.314416
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