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Glycoprotein 130 Signaling Regulates Notch1Expression and Activation in the Self-Renewal of Mammalian Forebrain Neural Stem Cells

Glycoprotein130 (gp130) and Notch signaling are thought to participate in neural stem cell (NSC) self-renewal. We asked whether gp130 regulates Notch activity in forebrain epidermal growth factor (EGF)-responsive NSCs. Disruption of Notch1 using antisense or a γ-secretase inhibitor demonstrated a re...

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Detalles Bibliográficos
Publicado en:J Neurosci
Main Authors: Chojnacki, Andrew, Shimazaki, Takuya, Gregg, Christopher, Weinmaster, Gerry, Weiss, Samuel
Formato: Artigo
Idioma:Inglês
Publicado: Society for Neuroscience 2003
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6741977/
https://ncbi.nlm.nih.gov/pubmed/12629177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.23-05-01730.2003
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