Assembly of α4β2 Nicotinic Acetylcholine Receptors Assessed with Functional Fluorescently Labeled Subunits: Effects of Localization, Trafficking, and Nicotine-Induced Upregulation in Clonal Mammalian Cells and in Cultured Midbrain Neurons

Fura-2 recording of Ca(2+) influx was used to show that incubation in 1 μm nicotine (2-6 d) upregulates several pharmacological components of acetylcholine (ACh) responses in ventral midbrain cultures, including a MLA-resistant, DHβE-sensitive component that presumably corresponds to α4β2 receptors....

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Bibliografiske detaljer
Udgivet i:J Neurosci
Main Authors: Nashmi, Raad, Dickinson, Mary E., McKinney, Sheri, Jareb, Mark, Labarca, Cesar, Fraser, Scott E., Lester, Henry A.
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2003
Fag:
Cellular/Molecular
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6740951/
https://ncbi.nlm.nih.gov/pubmed/14684858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.23-37-11554.2003
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