κ-Opioid Agonists Directly Inhibit Midbrain Dopaminergic Neurons

Dopaminergic neurons of the ventral tegmental area (VTA) play a critical role in motivation and reinforcement of goal-directed behaviors. Furthermore, excitation of these neurons has been implicated in the addictive process initiated by drugs such as morphine that act at the μ-opioid receptor (MOR)....

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Bibliographic Details
Published in:J Neurosci
Main Authors: Margolis, Elyssa B., Hjelmstad, Gregory O., Bonci, Antonello, Fields, Howard L.
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2003
Subjects:
Behavioral/Systems/Cognitive
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6740851/
https://ncbi.nlm.nih.gov/pubmed/14602811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.23-31-09981.2003
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