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A structural mechanism for phosphorylation-dependent inactivation of the AP2 complex
Endocytosis of transmembrane proteins is orchestrated by the AP2 clathrin adaptor complex. AP2 dwells in a closed, inactive state in the cytosol, but adopts an open, active conformation on the plasma membrane. Membrane-activated complexes are also phosphorylated, but the significance of this mark is...
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| Publicado en: | eLife |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
eLife Sciences Publications, Ltd
2019
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6739873/ https://ncbi.nlm.nih.gov/pubmed/31464684 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.50003 |
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