The membrane-associated proteins FCHo and SGIP are allosteric activators of the AP2 clathrin adaptor complex

The AP2 clathrin adaptor complex links protein cargo to the endocytic machinery but it is unclear how AP2 is activated on the plasma membrane. Here we demonstrate that the membrane-associated proteins FCHo and SGIP1 convert AP2 into an open, active conformation. We screened for Caenorhabditis elegan...

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Detalhes bibliográficos
Main Authors: Hollopeter, Gunther, Lange, Jeffrey J, Zhang, Ying, Vu, Thien N, Gu, Mingyu, Ailion, Michael, Lambie, Eric J, Slaughter, Brian D, Unruh, Jay R, Florens, Laurence, Jorgensen, Erik M
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2014
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4215536/
https://ncbi.nlm.nih.gov/pubmed/25303366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.03648
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