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The membrane-associated proteins FCHo and SGIP are allosteric activators of the AP2 clathrin adaptor complex
The AP2 clathrin adaptor complex links protein cargo to the endocytic machinery but it is unclear how AP2 is activated on the plasma membrane. Here we demonstrate that the membrane-associated proteins FCHo and SGIP1 convert AP2 into an open, active conformation. We screened for Caenorhabditis elegan...
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| 主要な著者: | , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
eLife Sciences Publications, Ltd
2014
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4215536/ https://ncbi.nlm.nih.gov/pubmed/25303366 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.03648 |
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