The membrane-associated proteins FCHo and SGIP are allosteric activators of the AP2 clathrin adaptor complex

The AP2 clathrin adaptor complex links protein cargo to the endocytic machinery but it is unclear how AP2 is activated on the plasma membrane. Here we demonstrate that the membrane-associated proteins FCHo and SGIP1 convert AP2 into an open, active conformation. We screened for Caenorhabditis elegan...

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Autores principales: Hollopeter, Gunther, Lange, Jeffrey J, Zhang, Ying, Vu, Thien N, Gu, Mingyu, Ailion, Michael, Lambie, Eric J, Slaughter, Brian D, Unruh, Jay R, Florens, Laurence, Jorgensen, Erik M
Formato: Artigo
Lenguaje:Inglês
Publicado: eLife Sciences Publications, Ltd 2014
Materias:
Cell Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4215536/
https://ncbi.nlm.nih.gov/pubmed/25303366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.03648
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