The membrane-associated proteins FCHo and SGIP are allosteric activators of the AP2 clathrin adaptor complex

The AP2 clathrin adaptor complex links protein cargo to the endocytic machinery but it is unclear how AP2 is activated on the plasma membrane. Here we demonstrate that the membrane-associated proteins FCHo and SGIP1 convert AP2 into an open, active conformation. We screened for Caenorhabditis elegan...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Hollopeter, Gunther, Lange, Jeffrey J, Zhang, Ying, Vu, Thien N, Gu, Mingyu, Ailion, Michael, Lambie, Eric J, Slaughter, Brian D, Unruh, Jay R, Florens, Laurence, Jorgensen, Erik M
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: eLife Sciences Publications, Ltd 2014
विषय:
Cell Biology
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC4215536/
https://ncbi.nlm.nih.gov/pubmed/25303366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.03648
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