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Substitution of cysteines in the yeast viral killer toxin K1 precursor reveals novel insights in heterodimer formation and immunity

The killer toxin K1 is a virally encoded fungal A/B toxin acting by disrupting plasma membrane integrity. The connection of α and β constitutes a critical feature for toxin biology and for decades the formation of three disulphide bonds linking the major toxin subunits was accepted as status quo. Du...

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Vydáno v:Sci Rep
Hlavní autoři: Gier, Stefanie, Lermen, Matthias, Schmitt, Manfred J., Breinig, Frank
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6739482/
https://ncbi.nlm.nih.gov/pubmed/31511600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-49621-z
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