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Bioinformatics Identification of Anti-CRISPR Loci by Using Homology, Guilt-by-Association, and CRISPR Self-Targeting Spacer Approaches

Anti-CRISPR (Acr) loci/operons encode Acr proteins and Acr-associated (Aca) proteins. Forty-five Acr families have been experimentally characterized inhibiting seven subtypes of CRISPR-Cas systems. We have developed a bioinformatics pipeline to identify genomic loci containing Acr homologs and/or Ac...

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Publicat a:mSystems
Autors principals: Yin, Yanbin, Yang, Bowen, Entwistle, Sarah
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2019
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6739104/
https://ncbi.nlm.nih.gov/pubmed/31506266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mSystems.00455-19
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