Ara-c induces cell cycle G1/S arrest by inducing upregulation of the INK4 family gene or directly inhibiting the formation of the cell cycle-dependent complex CDK4/cyclin D1

Cytosine arabinoside (Ara-c) is a pyrimidine anti-metabolite that is capable of interfering with cellular proliferation by inhibiting DNA synthesis. Each inhibitor of cyclin-dependent kinase 4 (INK4) family member has the ability to bind to cyclin-dependent kinase 4 (CDK4) and inhibit the formation...

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Bibliographische Detailangaben
Veröffentlicht in:Cell Cycle
Hauptverfasser: Sun, Fuze, Li, Niannian, Tong, Xiaoling, Zeng, Jie, He, Songzhen, Gai, Tingting, Bai, Yanmin, Liu, Lanlan, Lu, Kunpeng, Shen, Jianghong, Han, Minjin, Lu, Cheng, Dai, Fangyin
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2019
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6738522/
https://ncbi.nlm.nih.gov/pubmed/31322047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2019.1644913
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