DNA methylation-based estimator of telomere length

Telomere length (TL) is associated with several aging-related diseases. Here, we present a DNA methylation estimator of TL (DNAmTL) based on 140 CpGs. Leukocyte DNAmTL is applicable across the entire age spectrum and is more strongly associated with age than measured leukocyte TL (LTL) (r ~-0.75 for...

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Gepubliceerd in:Aging (Albany NY)
Hoofdauteurs: Lu, Ake T., Seeboth, Anne, Tsai, Pei-Chien, Sun, Dianjianyi, Quach, Austin, Reiner, Alex P., Kooperberg, Charles, Ferrucci, Luigi, Hou, Lifang, Baccarelli, Andrea A., Li, Yun, Harris, Sarah E., Corley, Janie, Taylor, Adele, Deary, Ian J., Stewart, James D., Whitsel, Eric A., Assimes, Themistocles L., Chen, Wei, Li, Shengxu, Mangino, Massimo, Bell, Jordana T., Wilson, James G., Aviv, Abraham, Marioni, Riccardo E., Raj, Kenneth, Horvath, Steve
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Impact Journals 2019
Onderwerpen:
Research Paper
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6738410/
https://ncbi.nlm.nih.gov/pubmed/31422385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.102173
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