DNA methylation-based estimator of telomere length

Telomere length (TL) is associated with several aging-related diseases. Here, we present a DNA methylation estimator of TL (DNAmTL) based on 140 CpGs. Leukocyte DNAmTL is applicable across the entire age spectrum and is more strongly associated with age than measured leukocyte TL (LTL) (r ~-0.75 for...

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Detalhes bibliográficos
Publicado no:Aging (Albany NY)
Main Authors: Lu, Ake T., Seeboth, Anne, Tsai, Pei-Chien, Sun, Dianjianyi, Quach, Austin, Reiner, Alex P., Kooperberg, Charles, Ferrucci, Luigi, Hou, Lifang, Baccarelli, Andrea A., Li, Yun, Harris, Sarah E., Corley, Janie, Taylor, Adele, Deary, Ian J., Stewart, James D., Whitsel, Eric A., Assimes, Themistocles L., Chen, Wei, Li, Shengxu, Mangino, Massimo, Bell, Jordana T., Wilson, James G., Aviv, Abraham, Marioni, Riccardo E., Raj, Kenneth, Horvath, Steve
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals 2019
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6738410/
https://ncbi.nlm.nih.gov/pubmed/31422385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.102173
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