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Characterization of the Pharmacokinetics of Samidorphan in Healthy Volunteers: Absolute Bioavailability and the Effect of Food and Age

BACKGROUND AND OBJECTIVES: Samidorphan (SAM) is a novel μ-opioid receptor antagonist. We report clinical pharmacokinetic (PK) properties of SAM following different routes of administration, and the effects of food and age on the PK of SAM following oral administration in healthy volunteers. METHODS:...

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Publicat a:Drugs R D
Autors principals: Kumar, Vipul, Lu, Hong, Hard, Marjie, von Moltke, Lisa
Format: Artigo
Idioma:Inglês
Publicat: Springer International Publishing 2019
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6738372/
https://ncbi.nlm.nih.gov/pubmed/31463821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40268-019-00280-5
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