Standardization of Sequencing Coverage Depth in NGS: Recommendation for Detection of Clonal and Subclonal Mutations in Cancer Diagnostics

The insufficient standardization of diagnostic next-generation sequencing (NGS) still limits its implementation in clinical practice, with the correct detection of mutations at low variant allele frequencies (VAF) facing particular challenges. We address here the standardization of sequencing covera...

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Detalhes bibliográficos
Publicado no:Front Oncol
Main Authors: Petrackova, Anna, Vasinek, Michal, Sedlarikova, Lenka, Dyskova, Tereza, Schneiderova, Petra, Novosad, Tomas, Papajik, Tomas, Kriegova, Eva
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6738196/
https://ncbi.nlm.nih.gov/pubmed/31552176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2019.00851
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