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Matrix protein Tenascin C expands and reversibly blocks maturation of murine eosinophil progenitors
We show that Tenascin-C, an asthma-associated extracellular matrix glycoprotein, promotes hematopoietic progenitors and suppresses the IL-5-driven maturation of murine lung eosinophils. The extracellular matrix’s regulation of in situ hematopoiesis has significant implications for targeting tissue e...
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| Veröffentlicht in: | J Allergy Clin Immunol |
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| Hauptverfasser: | , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6737931/ https://ncbi.nlm.nih.gov/pubmed/29705244 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2018.02.054 |
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