Depletion of phosphatidylinositol 4-phosphate at the Golgi translocates K-Ras to mitochondria

Ras proteins are small GTPases localized to the plasma membrane (PM), which regulate cellular proliferation, apoptosis and differentiation. After a series of post-translational modifications, H-Ras and N-Ras traffic to the PM from the Golgi via the classical exocytic pathway, but the exact mechanism...

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Foilsithe in:J Cell Sci
Main Authors: Miller, Taylor E., Henkels, Karen M., Huddleston, Mary, Salisbury, Richard, Hussain, Saber M., Sasaki, Atsuo T., Cho, Kwang-Jin
Formáid: Artigo
Teanga:Inglês
Foilsithe: The Company of Biologists Ltd 2019
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6737909/
https://ncbi.nlm.nih.gov/pubmed/31331963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.231886
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