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Changes in cardiac resident fibroblast physiology and phenotype in aging
The cardiac fibroblast plays a central role in tissue homeostasis and in repair after injury. With aging, dysregulated cardiac fibroblasts have a reduced capacity to activate a canonical transforming growth factor-β-Smad pathway and differentiate poorly into contractile myofibroblasts. That results...
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| Udgivet i: | Am J Physiol Heart Circ Physiol |
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| Main Authors: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Physiological Society
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6737453/ https://ncbi.nlm.nih.gov/pubmed/29906228 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00237.2018 |
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