Substrate docking–mediated specific and efficient lysine methylation by the SET domain–containing histone methyltransferase SETD7

Lysine methylation of cellular proteins is catalyzed by dozens of lysine methyltransferases (KMTs), occurs in thousands of different histone and nonhistone proteins, and regulates diverse biological processes. Dysregulation of KMT-mediated lysine methylations underlies many human diseases. A key una...

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Gepubliceerd in:J Biol Chem
Hoofdauteurs: Liu, Haiyang, Li, Zhiwei, Yang, Qingqing, Liu, Wei, Wan, Jun, Li, Jianchao, Zhang, Mingjie
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2019
Onderwerpen:
Enzymology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6737232/
https://ncbi.nlm.nih.gov/pubmed/31324717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.009630
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