Substrate docking–mediated specific and efficient lysine methylation by the SET domain–containing histone methyltransferase SETD7

Lysine methylation of cellular proteins is catalyzed by dozens of lysine methyltransferases (KMTs), occurs in thousands of different histone and nonhistone proteins, and regulates diverse biological processes. Dysregulation of KMT-mediated lysine methylations underlies many human diseases. A key una...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Liu, Haiyang, Li, Zhiwei, Yang, Qingqing, Liu, Wei, Wan, Jun, Li, Jianchao, Zhang, Mingjie
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2019
Fag:
Enzymology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6737232/
https://ncbi.nlm.nih.gov/pubmed/31324717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.009630
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