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DOCK8 is expressed in microglia, and it regulates microglial activity during neurodegeneration in murine disease models
Dedicator of cytokinesis 8 (DOCK8) is a guanine nucleotide exchange factor whose loss of function results in immunodeficiency, but its role in the central nervous system (CNS) has been unclear. Microglia are the resident immune cells of the CNS and are implicated in the pathogenesis of various neuro...
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| Опубликовано в: : | J Biol Chem |
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| Главные авторы: | , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Biochemistry and Molecular Biology
2019
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6737224/ https://ncbi.nlm.nih.gov/pubmed/31337702 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.007645 |
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