Abrogation of FBW7α-dependent p53 degradation enhances p53's function as a tumor suppressor

The gene encoding the tumor suppressor p53 is mutated in most cancers. p53 expression is known to be tightly controlled by several E3 ligases. Here, we show that F-box and WD repeat domain-containing 7α (FBW7α), the substrate-recognition component of the SCF(FBW7) multiprotein E3 ligase complex, tar...

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Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Tripathi, Vivek, Kaur, Ekjot, Kharat, Suhas Sampat, Hussain, Mansoor, Damodaran, Arun Prasath, Kulshrestha, Swati, Sengupta, Sagar
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2019
Soggetti:
Accelerated Communications
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6737220/
https://ncbi.nlm.nih.gov/pubmed/31346036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.AC119.008483
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