Metal-triggered conformational reorientation of a self-peptide bound to a disease-associated HLA-B*27 subtype

Conformational changes of major histocompatibility complex (MHC) antigens have the potential to be recognized by T cells and may arise from polymorphic variation of the MHC molecule, the binding of modifying ligands, or both. Here, we investigated whether metal ions could affect allele-dependent str...

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Vydáno v:J Biol Chem
Hlavní autoři: Driller, Ronja, Ballaschk, Martin, Schmieder, Peter, Uchanska-Ziegler, Barbara, Ziegler, Andreas, Loll, Bernhard
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2019
Témata:
Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6737219/
https://ncbi.nlm.nih.gov/pubmed/31296658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.008937
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