Down-regulation of cyclin-dependent kinase 5 attenuates p53-dependent apoptosis of hippocampal CA1 pyramidal neurons following transient cerebral ischemia

Abnormal activation of cyclin-dependent kinase 5 (Cdk5) is associated with pathophysiological conditions. Ischemic preconditioning (IPC) can provide neuroprotective effects against subsequent lethal ischemic insult. The objective of this study was to determine how Cdk5 and related molecules could af...

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Publicado en:Sci Rep
Autores principales: Shin, Bich Na, Kim, Dae Won, Kim, In Hye, Park, Joon Ha, Ahn, Ji Hyeon, Kang, Il Jun, Lee, Yun Lyul, Lee, Choong-Hyun, Hwang, In Koo, Kim, Young-Myeong, Ryoo, Sungwoo, Lee, Tae-Kyeong, Won, Moo-Ho, Lee, Jae-Chul
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6737192/
https://ncbi.nlm.nih.gov/pubmed/31506563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-49623-x
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