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Biological surface properties in extracellular vesicles and their effect on cargo proteins

Ultracentrifugationon sucrose density gradientappears to be the best purification protocol for extracellular vesicle (EVs) purification. After this step, to reduce disulfide bridges linking exogenous proteins to the vesicles, the collected samples are routinely washed and treated with dithiothreitol...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Sci Rep
Hauptverfasser: Santucci, Laura, Bruschi, Maurizio, Del Zotto, Genny, Antonini, Francesca, Ghiggeri, Gian Marco, Panfoli, Isabella, Candiano, Giovanni
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2019
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6736982/
https://ncbi.nlm.nih.gov/pubmed/31506490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-47598-3
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