Locus coeruleus imaging as a biomarker for noradrenergic dysfunction in neurodegenerative diseases

Pathological alterations to the locus coeruleus, the major source of noradrenaline in the brain, are histologically evident in early stages of neurodegenerative diseases. Novel MRI approaches now provide an opportunity to quantify structural features of the locus coeruleus in vivo during disease pro...

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Publicado en:Brain
Autores principales: Betts, Matthew J, Kirilina, Evgeniya, Otaduy, Maria C G, Ivanov, Dimo, Acosta-Cabronero, Julio, Callaghan, Martina F, Lambert, Christian, Cardenas-Blanco, Arturo, Pine, Kerrin, Passamonti, Luca, Loane, Clare, Keuken, Max C, Trujillo, Paula, Lüsebrink, Falk, Mattern, Hendrik, Liu, Kathy Y, Priovoulos, Nikos, Fliessbach, Klaus, Dahl, Martin J, Maaß, Anne, Madelung, Christopher F, Meder, David, Ehrenberg, Alexander J, Speck, Oliver, Weiskopf, Nikolaus, Dolan, Raymond, Inglis, Ben, Tosun, Duygu, Morawski, Markus, Zucca, Fabio A, Siebner, Hartwig R, Mather, Mara, Uludag, Kamil, Heinsen, Helmut, Poser, Benedikt A, Howard, Robert, Zecca, Luigi, Rowe, James B, Grinberg, Lea T, Jacobs, Heidi I L, Düzel, Emrah, Hämmerer, Dorothea
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2019
Materias:
Update
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6736046/
https://ncbi.nlm.nih.gov/pubmed/31327002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/awz193
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