Locus coeruleus imaging as a biomarker for noradrenergic dysfunction in neurodegenerative diseases

Pathological alterations to the locus coeruleus, the major source of noradrenaline in the brain, are histologically evident in early stages of neurodegenerative diseases. Novel MRI approaches now provide an opportunity to quantify structural features of the locus coeruleus in vivo during disease pro...

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Veröffentlicht in:Brain
Hauptverfasser: Betts, Matthew J, Kirilina, Evgeniya, Otaduy, Maria C G, Ivanov, Dimo, Acosta-Cabronero, Julio, Callaghan, Martina F, Lambert, Christian, Cardenas-Blanco, Arturo, Pine, Kerrin, Passamonti, Luca, Loane, Clare, Keuken, Max C, Trujillo, Paula, Lüsebrink, Falk, Mattern, Hendrik, Liu, Kathy Y, Priovoulos, Nikos, Fliessbach, Klaus, Dahl, Martin J, Maaß, Anne, Madelung, Christopher F, Meder, David, Ehrenberg, Alexander J, Speck, Oliver, Weiskopf, Nikolaus, Dolan, Raymond, Inglis, Ben, Tosun, Duygu, Morawski, Markus, Zucca, Fabio A, Siebner, Hartwig R, Mather, Mara, Uludag, Kamil, Heinsen, Helmut, Poser, Benedikt A, Howard, Robert, Zecca, Luigi, Rowe, James B, Grinberg, Lea T, Jacobs, Heidi I L, Düzel, Emrah, Hämmerer, Dorothea
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2019
Schlagworte:
Update
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6736046/
https://ncbi.nlm.nih.gov/pubmed/31327002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/awz193
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