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p53 balances between tissue hierarchy and anarchy

Normal tissues are organized in a hierarchical model, whereas at the apex of these hierarchies reside stem cells (SCs) capable of self-renewal and of producing differentiated cellular progenies, leading to normal development and homeostasis. Alike, tumors are organized in a hierarchical manner, with...

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Bibliographic Details
Published in:J Mol Cell Biol
Main Authors: Koifman, Gabriela, Aloni-Grinstein, Ronit, Rotter, Varda
Format: Artigo
Language:Inglês
Published: Oxford University Press 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6735948/
https://ncbi.nlm.nih.gov/pubmed/30925590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jmcb/mjz022
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