DNA complexes with human apurinic/apyrimidinic endonuclease 1: structural insights revealed by pulsed dipolar EPR with orthogonal spin labeling

A DNA molecule is under continuous influence of endogenous and exogenous damaging factors, which produce a variety of DNA lesions. Apurinic/apyrimidinic sites (abasic or AP sites) are among the most common DNA lesions. In this work, we applied pulse dipolar electron paramagnetic resonance (EPR) spec...

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Détails bibliographiques
Publié dans:Nucleic Acids Res
Auteurs principaux: Krumkacheva, Olesya A, Shevelev, Georgiy Yu, Lomzov, Alexander A, Dyrkheeva, Nadezhda S, Kuzhelev, Andrey A, Koval, Vladimir V, Tormyshev, Victor M, Polienko, Yuliya F, Fedin, Matvey V, Pyshnyi, Dmitrii V, Lavrik, Olga I, Bagryanskaya, Elena G
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2019
Sujets:
Chemical Biology and Nucleic Acid Chemistry
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6735896/
https://ncbi.nlm.nih.gov/pubmed/31329919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz620
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