Double-strand breaks in ribosomal RNA genes activate a distinct signaling and chromatin response to facilitate nucleolar restructuring and repair

The nucleolus is a nuclear sub-domain containing the most highly transcribed genes in the genome. Hundreds of human ribosomal RNA (rRNA) genes, located in the nucleolus, rely on constant maintenance. DNA double-strand breaks (DSBs) in rRNA genes activate the ATM kinase, repress rRNA transcription an...

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Bibliografske podrobnosti
izdano v:Nucleic Acids Res
Main Authors: Korsholm, Lea M, Gál, Zita, Lin, Lin, Quevedo, Oliver, Ahmad, Diana A, Dulina, Ekaterina, Luo, Yonglun, Bartek, Jiri, Larsen, Dorthe H
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2019
Teme:
Genome Integrity, Repair and Replication
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6735822/
https://ncbi.nlm.nih.gov/pubmed/31184714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz518
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