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Differences in mutational processes and intra-tumour heterogeneity between organs: The local selective filter hypothesis

Extensive diversity (genetic, cytogenetic, epigenetic and phenotypic) exists within and between tumours, but reasons behind these variations, as well as their consistent hierarchical pattern between organs, are poorly understood at the moment. We argue that these phenomena are, at least partially, e...

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Опубликовано в: :Evol Med Public Health
Главные авторы: Giraudeau, Mathieu, Sepp, Tuul, Ujvari, Beata, Renaud, François, Tasiemski, Aurélie, Roche, Benjamin, Capp, Jean-Pascal, Thomas, Frédéric
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2019
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6735757/
https://ncbi.nlm.nih.gov/pubmed/31528343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emph/eoz017
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