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Differences in mutational processes and intra-tumour heterogeneity between organs: The local selective filter hypothesis

Extensive diversity (genetic, cytogenetic, epigenetic and phenotypic) exists within and between tumours, but reasons behind these variations, as well as their consistent hierarchical pattern between organs, are poorly understood at the moment. We argue that these phenomena are, at least partially, e...

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Détails bibliographiques
Publié dans:Evol Med Public Health
Auteurs principaux: Giraudeau, Mathieu, Sepp, Tuul, Ujvari, Beata, Renaud, François, Tasiemski, Aurélie, Roche, Benjamin, Capp, Jean-Pascal, Thomas, Frédéric
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2019
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6735757/
https://ncbi.nlm.nih.gov/pubmed/31528343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emph/eoz017
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