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Differences in mutational processes and intra-tumour heterogeneity between organs: The local selective filter hypothesis

Extensive diversity (genetic, cytogenetic, epigenetic and phenotypic) exists within and between tumours, but reasons behind these variations, as well as their consistent hierarchical pattern between organs, are poorly understood at the moment. We argue that these phenomena are, at least partially, e...

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Detalhes bibliográficos
Publicado no:Evol Med Public Health
Main Authors: Giraudeau, Mathieu, Sepp, Tuul, Ujvari, Beata, Renaud, François, Tasiemski, Aurélie, Roche, Benjamin, Capp, Jean-Pascal, Thomas, Frédéric
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6735757/
https://ncbi.nlm.nih.gov/pubmed/31528343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emph/eoz017
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