Early postnatal overnutrition accelerates aging-associated epigenetic drift in pancreatic islets

Pancreatic islets of type 2 diabetes patients have altered DNA methylation, contributing to islet dysfunction and the onset of type 2 diabetes. The cause of these epigenetic alterations is largely unknown. We set out to test whether (i) islet DNA methylation would change with aging and (ii) early po...

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Bibliografische gegevens
Gepubliceerd in:Environ Epigenet
Hoofdauteurs: Li, Ge, Petkova, Tihomira D, Laritsky, Eleonora, Kessler, Noah, Baker, Maria S, Zhu, Shaoyu, Waterland, Robert A
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2019
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6735752/
https://ncbi.nlm.nih.gov/pubmed/31528363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/eep/dvz015
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