The ionophore oxyclozanide enhances tobramycin killing of Pseudomonas aeruginosa biofilms by permeabilizing cells and depolarizing the membrane potential

OBJECTIVES: To assess the ability of oxyclozanide to enhance tobramycin killing of Pseudomonas aeruginosa biofilms and elucidate its mechanism of action. METHODS: Twenty-four hour biofilms formed by the P. aeruginosa strain PAO1 and cystic fibrosis (CF) isolates were tested for susceptibility to oxy...

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Veröffentlicht in:J Antimicrob Chemother
Hauptverfasser: Maiden, Michael M, Zachos, Mitchell P, Waters, Christopher M
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2019
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Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6735725/
https://ncbi.nlm.nih.gov/pubmed/30624737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dky545
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