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Structure–activity relationships of furazano[3,4-b]pyrazines as mitochondrial uncouplers

Chemical mitochondrial uncouplers are lipophilic weak acids that transport protons into the mitochondrial matrix via a pathway that is independent of ATP synthase, thereby uncoupling nutrient oxidation from ATP production. These uncouplers have potential for the treatment of diseases such as obesity...

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Bibliografiske detaljer
Udgivet i:Bioorg Med Chem Lett
Main Authors: Kenwood, Brandon M., Calderone, Joseph A., Taddeo, Evan P., Hoehn, Kyle L., Santos, Webster L.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6734931/
https://ncbi.nlm.nih.gov/pubmed/26119501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2015.06.040
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