Identification of a novel mitochondrial uncoupler that does not depolarize the plasma membrane()

Dysregulation of oxidative phosphorylation is associated with increased mitochondrial reactive oxygen species production and some of the most prevalent human diseases including obesity, cancer, diabetes, neurodegeneration, and heart disease. Chemical 'mitochondrial uncouplers' are lipophil...

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Main Authors: Kenwood, Brandon M., Weaver, Janelle L., Bajwa, Amandeep, Poon, Ivan K., Byrne, Frances L., Murrow, Beverley A., Calderone, Joseph A., Huang, Liping, Divakaruni, Ajit S., Tomsig, Jose L., Okabe, Kohki, Lo, Ryan H., Cameron Coleman, G., Columbus, Linda, Yan, Zhen, Saucerman, Jeffrey J., Smith, Jeffrey S., Holmes, Jeffrey W., Lynch, Kevin R., Ravichandran, Kodi S., Uchiyama, Seiichi, Santos, Webster L., Rogers, George W., Okusa, Mark D., Bayliss, Douglas A., Hoehn, Kyle L.
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2013
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3953706/
https://ncbi.nlm.nih.gov/pubmed/24634817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2013.11.005
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