Protein kinase D increases maximal Ca(2+)-activated tension of cardiomyocyte contraction by phosphorylation of cMyBP-C-Ser(315)

Cardiac myosin-binding protein C (cMyBP-C) is involved in the regulation of cardiac myofilament contraction. Recent evidence showed that protein kinase D (PKD) is one of the kinases that phosphorylate cMyBP-C. However, the mechanism by which PKD-induced cMyBP-C phosphorylation affects cardiac contra...

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Veröffentlicht in:Am J Physiol Heart Circ Physiol
Hauptverfasser: Dirkx, Ellen, Cazorla, Olivier, Schwenk, Robert W., Lorenzen-Schmidt, Ilka, Sadayappan, Sakthivel, Van Lint, Johan, Carrier, Lucie, van Eys, Guillaume J. J. M., Glatz, Jan F. C., Luiken, Joost J. F. P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2012
Schlagworte:
Muscle Mechanics and Ventricular Function
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6734090/
https://ncbi.nlm.nih.gov/pubmed/22636676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00749.2011
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