Humanin analog enhances the protective effect of dexrazoxane against doxorubicin-induced cardiotoxicity

The chemotherapeutic effect of doxorubicin (Dox) is limited by cumulative dose-dependent cardiotoxicity in cancer survivors. Dexrazoxane (DRZ) is approved to prevent Dox-induced cardiotoxicity. Humanin and its synthetic analog HNG have a cytoprotective effect on the heart. To investigate the cardiop...

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Veröffentlicht in:Am J Physiol Heart Circ Physiol
Hauptverfasser: Lue, Yanhe, Gao, Chen, Swerdloff, Ronald, Hoang, James, Avetisyan, Rozeta, Jia, Yue, Rao, Meng, Ren, Shuxun, Atienza, Vince, Yu, Junyi, Zhang, Ye, Chen, Mengping, Song, Yang, Wang, Yibin, Wang, Christina
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2018
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6734085/
https://ncbi.nlm.nih.gov/pubmed/29775411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00155.2018
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