Mitochondrial dysfunction in iPSC-derived neurons of subjects with chronic mountain sickness

Patients with chronic mountain sickness (CMS) suffer from hypoxemia, erythrocytosis, and numerous neurologic deficits. Here we used induced pluripotent stem cell (iPSC)-derived neurons from both CMS and non-CMS subjects to study CMS neuropathology. Using transmission electron microscopy, we report t...

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Bibliographic Details
Published in:J Appl Physiol (1985)
Main Authors: Zhao, Helen, Perkins, Guy, Yao, Hang, Callacondo, David, Appenzeller, Otto, Ellisman, Mark, La Spada, Albert R., Haddad, Gabriel G.
Format: Artigo
Language:Inglês
Published: American Physiological Society 2018
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6734077/
https://ncbi.nlm.nih.gov/pubmed/29357502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/japplphysiol.00689.2017
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