Exploring use of unsupervised clustering to associate signaling profiles of GPCR ligands to clinical response

Signaling diversity of G protein-coupled (GPCR) ligands provides novel opportunities to develop more effective, better-tolerated therapeutics. Taking advantage of these opportunities requires identifying which effectors should be specifically activated or avoided so as to promote desired clinical re...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Benredjem, Besma, Gallion, Jonathan, Pelletier, Dennis, Dallaire, Paul, Charbonneau, Johanie, Cawkill, Darren, Nagi, Karim, Gosink, Mark, Lukasheva, Viktoryia, Jenkinson, Stephen, Ren, Yong, Somps, Christopher, Murat, Brigitte, Van Der Westhuizen, Emma, Le Gouill, Christian, Lichtarge, Olivier, Schmidt, Anne, Bouvier, Michel, Pineyro, Graciela
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6733853/
https://ncbi.nlm.nih.gov/pubmed/31501422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-11875-6
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