Shaping of infant B cell receptor repertoires by environmental factors and infectious disease

Antigenic exposures at epithelial sites in infancy and early childhood are thought to influence the maturation of humoral immunity and modulate the risk of developing IgE-mediated allergic disease. How different kinds of environmental exposures influence B cell isotype switching to IgE, IgG, or IgA,...

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Pubblicato in:Sci Transl Med
Autori principali: Nielsen, Sandra C. A., Roskin, Krishna M., Jackson, Katherine J. L., Joshi, Shilpa A., Nejad, Parastu, Lee, Ji-Yeun, Wagar, Lisa E., Pham, Tho D., Hoh, Ramona A., Nguyen, Khoa D., Tsunemoto, Hannah Y., Patel, Sonal B., Tibshirani, Robert, Ley, Catherine, Davis, Mark M., Parsonnet, Julie, Boyd, Scott D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6733608/
https://ncbi.nlm.nih.gov/pubmed/30814336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aat2004
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