EV71 3C protease induces apoptosis by cleavage of hnRNP A1 to promote apaf-1 translation

Enterovirus 71 (EV71) induces apoptosis to promote viral particle release. Earlier work showed that EV71 utilizes its 3C protease to induce apoptosis in a caspase-3-dependent pathway, though the mechanism is unknown. However, work from Vagner, Holcik and colleagues showed that host protein heterogen...

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Udgivet i:PLoS One
Main Authors: Li, Mei-Ling, Lin, Jing-Yi, Chen, Bo-Shiun, Weng, Kuo-Feng, Shih, Shin-Ru, Calderon, Jesse Davila, Tolbert, Blanton S., Brewer, Gary
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6733512/
https://ncbi.nlm.nih.gov/pubmed/31498791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0221048
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