Engineering Hyaline Cartilage from Mesenchymal Stem Cells with Low Hypertrophy Potential via Modulation of Culture Conditions and Wnt/β-Catenin Pathway

Mesenchymal stem cells (MSCs) represent a promising cell source to regenerate articular cartilage, but current chondroinduction protocols, commonly using transforming growth factor-β (TGFβ), lead to concomitant chondrocytic hypertrophy with ossification risk. Here, we showed that a 14-day culture of...

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Publicado no:Biomaterials
Main Authors: Deng, Yuhao, Lei, Guanghua, Lin, Zixuan, Yang, Yuanheng, Lin, Hang, Tuan, Rocky S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6733256/
https://ncbi.nlm.nih.gov/pubmed/30544046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2018.11.036
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