Interleukin-1 receptor activation aggravates autosomal dominant polycystic kidney disease by modulating regulated necrosis

Autosomal dominant polycystic kidney disease (ADPKD) is associated with increased chemokines, cytokines, and growth factors in the diseased kidney. We found that both isoforms of IL-1, IL-1α and IL-1β, were upregulated in ADPKD tissues. Here, we used a unique murine ADPKD model with selective deleti...

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Vydáno v:Am J Physiol Renal Physiol
Hlavní autoři: Yang, Bo, Fu, Lili, Privratsky, Jamie R., Lu, Xiaohan, Ren, Jiafa, Mei, Changlin, Crowley, Steven D.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2019
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6732457/
https://ncbi.nlm.nih.gov/pubmed/31141402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00104.2019
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