Interleukin-1 receptor activation aggravates autosomal dominant polycystic kidney disease by modulating regulated necrosis

Autosomal dominant polycystic kidney disease (ADPKD) is associated with increased chemokines, cytokines, and growth factors in the diseased kidney. We found that both isoforms of IL-1, IL-1α and IL-1β, were upregulated in ADPKD tissues. Here, we used a unique murine ADPKD model with selective deleti...

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Detalhes bibliográficos
Publicado no:Am J Physiol Renal Physiol
Main Authors: Yang, Bo, Fu, Lili, Privratsky, Jamie R., Lu, Xiaohan, Ren, Jiafa, Mei, Changlin, Crowley, Steven D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6732457/
https://ncbi.nlm.nih.gov/pubmed/31141402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00104.2019
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