Effect of renal tubule-specific knockdown of the Na(+)/H(+) exchanger NHE3 in Akita diabetic mice

Na(+)/H(+) exchanger isoform 3 (NHE3) contributes to Na(+)/bicarbonate reabsorption and ammonium secretion in early proximal tubules. To determine its role in the diabetic kidney, type 1 diabetic Akita mice with tubular NHE3 knockdown [Pax8-Cre; NHE3-knockout (KO) mice] were generated. NHE3-KO mice...

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Veröffentlicht in:Am J Physiol Renal Physiol
Hauptverfasser: Onishi, Akira, Fu, Yiling, Darshi, Manjula, Crespo-Masip, Maria, Huang, Winnie, Song, Panai, Patel, Rohit, Kim, Young Chul, Nespoux, Josselin, Freeman, Brent, Soleimani, Manoocher, Thomson, Scott, Sharma, Kumar, Vallon, Volker
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2019
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6732454/
https://ncbi.nlm.nih.gov/pubmed/31166707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00497.2018
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