The role of GIP and pancreatic GLP-1 in the glucoregulatory effect of DPP-4 inhibition in mice

AIMS/HYPOTHESIS: Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are two peptides that function to promote insulin secretion. Dipeptidyl peptidase-4 (DPP-4) inhibitors increase the bioavailability of both GLP-1 and GIP but the dogma continues to be that it is t...

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Publicat a:Diabetologia
Autors principals: Hutch, Chelsea R., Roelofs, Karen, Haller, April, Sorrell, Joyce, Leix, Kyle, D’Alessio, David D., Augustin, Robert, Seeley, Randy J., Klein, Thomas, Sandoval, Darleen A.
Format: Artigo
Idioma:Inglês
Publicat: 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6732043/
https://ncbi.nlm.nih.gov/pubmed/31414143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-019-4963-5
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