High-Affinity Binding of Chemokine Analogs that Display Ligand Bias at the HIV-1 Coreceptor CCR5

The chemokine receptor CCR5 is a drug target to prevent transmission of HIV/AIDS. We studied four analogs of the native chemokine regulated, on activation, normal T-cell-expressed, and secreted (RANTES) (CCL5) that have anti-HIV potencies of around 25 pM, which is more than four orders of magnitude...

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Detalhes bibliográficos
Publicado no:Biophys J
Main Authors: Rico, Carlos A., Berchiche, Yamina A., Horioka, Mizuho, Peeler, Jennifer C., Lorenzen, Emily, Tian, He, Kazmi, Manija A., Fürstenberg, Alexandre, Gaertner, Hubert, Hartley, Oliver, Sakmar, Thomas P., Huber, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2019
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6731458/
https://ncbi.nlm.nih.gov/pubmed/31421836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2019.07.043
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