CC Chemokine Receptor 5 (CCR5) Desensitization: CYCLING RECEPTORS ACCUMULATE IN THE TRANS-GOLGI NETWORK

CC chemokine receptor 5 (CCR5), the major HIV coreceptor, is a G protein-coupled receptor (GPCR) involved in cell activation and migration in response to chemokines. Blockade of CCR5 is an effective anti-HIV strategy, and potent anti-HIV chemokine analogs such as PSC-RANTES have been developed. Thes...

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Bibliografiske detaljer
Main Authors: Escola, Jean-Michel, Kuenzi, Gabriel, Gaertner, Hubert, Foti, Michelangelo, Hartley, Oliver
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2010
Fag:
Cell Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3009905/
https://ncbi.nlm.nih.gov/pubmed/21041313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.153460
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